Evidence Supporting the Connection Between Prostaglandin Deficiency and Schizophrenia

So I mentioned this in my last post, but the following are observations supporting the link between prostaglandin deficiency and schizophrenia:

1. Arthritis is partly mediated by prostaglandins (4). Schizophrenics have significantly lower rates of arthritis (1,2,3).

2. Niacin can cause vasodilation (”flushing”), a process mediated by prostaglandins (7,8,9). Schizophrenics experience this flushing significantly less than the general population (5,6).

NSAID’s are drugs that block prostaglandin production. Thus, one might expect the effects of taking NSAID’s to be also seen in schizophrenics:

3. NSAID’s increase intestinal permeability (14,18,21). Schizophrenics seem to have greater intestinal permeability (13).

4. NSAID’s decrease risk of cancer (25-31). Schizophrenics have been shown to have a lower risk of cancer (15,16).

5. NSAID’s increase gluten sensitivity in animals (24). Schizophrenics have greater rates of gluten sensitivity (22,23).

6. Finally, polyunsaturated fatty acids (or PUFA’s) are necessary substrates for prostaglandin production. PUFA deficits are associated with worsened schizophrenic symptoms (10) and a lower PUFA content of phospholipids and the frontal cortex have been observed in schizophrenics (11,12).

I will likely amend this list and add more as I find them.

1. http://www.sciencedirect.com/science/article/pii/092099649290001L
2. http://www.psycontent.com/content/14u18472l7647408/
3. http://psycnet.apa.org/journals/szb/17/4/669/
4. http://www.jci.org/articles/view/15528
5. http://www.sciencedirect.com/science/article/pii/S092099649700100X
6. http://www.sciencedirect.com/science/article/pii/S0920996402002815
7. http://www.nature.com/jid/journal/v98/n5/abs/5612129a.html
8. http://www.nature.com/clpt/journal/v81/n6/abs/6100180a.html
9. http://www.sciencedirect.com/science/article/pii/0090698089900889
10. http://www.sciencedirect.com/science/article/pii/S095232781000116X
11. http://www.ncbi.nlm.nih.gov/pubmed/12372654?dopt=Abstract&holding=npg
12. http://www.ncbi.nlm.nih.gov/pubmed/1751622?dopt=Abstract&holding=npg
13. http://bjp.rcpsych.org/content/150/6/853.short
14. http://gut.bmj.com/content/27/11/1292.abstract
15. http://onlinelibrary.wiley.com/doi/10.1002/cncr.21574/full
16. http://www.sciencedirect.com/science/article/pii/S0920996404002130
18. http://gut.bmj.com/content/43/4/506.abstract
19. http://archpsyc.jamanetwork.com/article.aspx?volume=58&issue=6&page=573
20. http://www.sciencedirect.com/science/article/pii/S0920996401003085
21. http://www.springerlink.com/content/e6u416578225g677/
22. http://www.ncbi.nlm.nih.gov/pubmed/19748229
23. http://www.ncbi.nlm.nih.gov/pubmed/20471632
24. http://www.ncbi.nlm.nih.gov/pubmed/19795413
25. http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1098-2744(199908)25:4%3C231::AID-MC1%3E3.0.CO;2-F/abstract
26. http://jn.nutrition.org/content/131/4/1125.abstract?ijkey=8ba8a50f5dbc2cc511435238d83ef7294b0061ec&keytype2=tf_ipsecsha
27. http://www.ncbi.nlm.nih.gov/pubmed/15998950
28. http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1098-2744(199908)25:4%3C231::AID-MC1%3E3.0.CO;2-F/abstract
29. http://www.ncbi.nlm.nih.gov/pubmed/15668504
30. http://www.ncbi.nlm.nih.gov/pubmed/15734963
31. http://www.ncbi.nlm.nih.gov/pubmed/8385741

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